Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment.
Ontology highlight
ABSTRACT: Background
We examined the research attitudes and willingness to participate in clinical research among cancer survivors with varying degrees of cognitive function.Methods
This is a secondary analysis of data collected through the University of California Irvine Consent-to-Contact registry. Cancer survivors completed the Cognitive Function Instrument (CFI), the Research Attitudes Questionnaire (RAQ), and willingness to participate (WTP) in certain research procedures. Perceived cognitive impairment (CI) was defined as the worst 20% CFI scores.Results
Here, 265 CI and 909 cognitively non-impaired (CNI) participants' data were analyzed. Mean age and sex distribution were similar, with fewer non-Hispanic Whites and education years among CI participants. More CI participants self-reported past diagnoses of Alzheimer's disease, mild cognitive impairment, stroke, depression, post-traumatic stress disorder, and alcohol abuse (all p < 0.05). CI participants were significantly more interested in studies investigating approved medications (92% vs. 87%, p = 0.030), lumbar puncture (47% vs. 38%, p = 0.027), and autopsy (78% vs. 69%, p = 0.022). After removing survivors with co-existing neuropsychiatric conditions, interest in autopsy studies remained statistically higher among CI (79% vs. 69%, p = 0.022).Conclusions
Participants with cancer and CI are open to research procedures and interventions that are traditionally less utilized, which may facilitate the discovery of the pathogenesis and interventions for cancer-related cognitive impairment (CRCI).
SUBMITTER: Ng DQ
PROVIDER: S-EPMC10340755 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Publications
Research Attitude and Interest among Cancer Survivors with or without Cognitive Impairment.
Ng Ding Quan DQ Chan Daniella D Acharya Munjal M MM Grill Joshua D JD Chan Alexandre A
Cancers 20230629 13
<h4>Background</h4>We examined the research attitudes and willingness to participate in clinical research among cancer survivors with varying degrees of cognitive function.<h4>Methods</h4>This is a secondary analysis of data collected through the University of California Irvine Consent-to-Contact registry. Cancer survivors completed the Cognitive Function Instrument (CFI), the Research Attitudes Questionnaire (RAQ), and willingness to participate (WTP) in certain research procedures. Perceived c ...[more]
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