Dataset Information

Fecal microbiota transplantation in patients with metabolic syndrome and obesity: A randomized controlled trial.

ABSTRACT:

Background

Metabolic syndrome is a multifactorial disease, and the gut microbiota may play a role in its pathogenesis. Obesity, especially abdominal obesity, is associated with insulin resistance, often increasing the risk of type two diabetes mellitus, vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation, all of which promote the development of atherosclerotic cardiovascular disease.

Aim

To evaluate the outcomes of fecal microbiota transplantation (FMT) in patients with metabolic syndrome.

Methods

This was a randomized, single-blind placebo-controlled trial comparing FMT and a sham procedure in patients with metabolic syndrome. We selected 32 female patients, who were divided into eight groups of four patients each. All of the patients were submitted to upper gastrointestinal endoscopy. In each group, two patients were randomly allocated to undergo FMT, and the other two patients received saline infusion. The patients were followed for one year after the procedures, during which time anthropometric, bioimpedance, and biochemical data were collected. The patients also had periodic consultations with a nutritionist and an endocrinologist. The primary end point was a change in the gut microbiota.

Results

There was evidence of a postprocedural change in microbiota composition in the patients who underwent FMT in relation to that observed in those who underwent the sham procedure. However, we found no difference between the two groups in terms of the clinical parameters evaluated.

Conclusion

There were no significant differences in biochemical or anthropometric parameters, between the two groups evaluated. Nevertheless, there were significant postprocedural differences in the microbiota composition between the placebo group. To date, clinical outcomes related to FMT remain uncertain.

SUBMITTER: da Ponte Neto AM

PROVIDER: S-EPMC10353513 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

Fecal microbiota transplantation in patients with metabolic syndrome and obesity: A randomized controlled trial.

da Ponte Neto Alberto Machado AM Clemente Aniele Cristine Ott ACO Rosa Paula Waki PW Ribeiro Igor Braga IB Funari Mateus Pereira MP Nunes Gabriel Cairo GC Moreira Luana L Sparvoli Luiz Gustavo LG Cortez Ramon R Taddei Carla Romano CR Mancini Márcio C MC de Moura Eduardo Guimarães Hourneaux EGH

World journal of clinical cases 20230701 19

<h4>Background</h4>Metabolic syndrome is a multifactorial disease, and the gut microbiota may play a role in its pathogenesis. Obesity, especially abdominal obesity, is associated with insulin resistance, often increasing the risk of type two diabetes mellitus, vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation, all of which promote the development of atherosclerotic cardiovascular disease.<h4>Aim</h4>To evaluate the outcomes of fecal microbiota ...[more]

PMID: 37469721

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Dataset Information

Fecal microbiota transplantation in patients with metabolic syndrome and obesity: A randomized controlled trial.

Background

Aim

Methods

Results

Conclusion

Publications

Fecal microbiota transplantation in patients with metabolic syndrome and obesity: A randomized controlled trial.

Similar Datasets

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