Microglia-Mediated Neuroimmune Response Regulates Cardiac Remodeling After Myocardial Infarction.

ABSTRACT: Background Sympathetic hyperactivity contributes to pathological remodeling after myocardial infarction (MI). However, the mechanisms underlying the increase in sympathetic activity remain unknown. Microglia are the predominant immune cells in the central nervous system and can regulate sympathetic neuron activity through neuroimmune response in the hypothalamic paraventricular nucleus. The present study aimed to investigate whether microglia-mediated neuroimmune response can regulate sympathetic activity and cardiac remodeling after MI. Methods and Results PLX3397 (pexidartinib) was used to deplete central microglia via intragastric injection or intracerebroventricular injection. After that, MI was induced by ligation of the left anterior descending coronary artery. Our study showed that

SUBMITTER: Wang M 

PROVIDER: S-EPMC10356026 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature