Plasma angiopoietin-2 and its association with heart failure in patients with atrial fibrillation.

ABSTRACT:

Aims

Several biomarkers are associated with clinical outcomes in patients with atrial fibrillation (AF), but a causal relationship has not been established. This study aimed to evaluate angiopoietin-2, a novel candidate biomarker of endothelial inflammation and vascular remodelling, in patients with AF.

Methods and results

Angiopoietin-2 was measured in plasma obtained from patients with AF treated with aspirin monotherapy (exploration cohort, n = 2987) or with oral anticoagulation (validation cohort, n = 13 079). Regression models were built to assess the associations between angiopoietin-2, clinical characteristics, and outcomes. In both cohorts, plasma angiopoietin-2 was independently associated with AF on the baseline electrocardiogram and persistent/permanent AF, age, h

SUBMITTER: Benz AP 

PROVIDER: S-EPMC10359110 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature