Tongue coating microbiome composition reflects disease severity in patients with COVID-19 in Nanjing, China.

ABSTRACT: Our purpose is to investigate the relationship between the microbiota of patients' tongue coating microbiota and the severity of COVID-19, and to identify the severity of COVID-19 patients' condition as early as possible. The participants were categorized into three groups: healthy controls (Con group) consisting of 37 individuals, patients with mild to moderate symptoms (M group) comprising 49 individuals, and patients with severe and critical symptoms (S-C group) consisting of 44 individuals. We collected oral swabs from all participants and performed 16S rRNA gene sequencing to analyze the microbiome. The α and β diversity differences were assessed respectively. Additionally, we employed the Linear Discriminant Analysis Effect Size (LEfSe) analysis to evaluate taxonomic differences amon

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC10360987 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature