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Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks.

ABSTRACT: Cardiac Purkinje networks are a fundamental part of the conduction system and are known to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje networks remains a challenge due to their high morphological complexity. This work presents a novel method based on optimization principles for the generation of Purkinje networks that combines geometric and activation accuracy in branch size, bifurcation angles, and Purkinje-ventricular-junction activation times. Three biventricular meshes with increasing levels of complexity are used to evaluate the performance of our approach. Purkinje-tissue coupled monodomain simulations are executed to evaluate the generated networks in a realistic scenario using the most recent Purkinje/ventricular human cellular models and physiological values for the Purkinje-ventricular-junction characteristic delay. The results demonstrate that the new method can generate patient-specific Purkinje networks with controlled morphological metrics and specified local activation times at the Purkinje-ventricular junctions.

SUBMITTER: Berg LA

PROVIDER: S-EPMC10362015 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks.

Berg Lucas Arantes LA Rocha Bernardo Martins BM Oliveira Rafael Sachetto RS Sebastian Rafael R Rodriguez Blanca B de Queiroz Rafael Alves Bonfim RAB Cherry Elizabeth M EM Dos Santos Rodrigo Weber RW

Scientific reports 20230721 1

Cardiac Purkinje networks are a fundamental part of the conduction system and are known to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje networks remains a challenge due to their high morphological complexity. This work presents a novel method based on optimization principles for the generation of Purkinje networks that combines geometric and activation accuracy in branch size, bifurcation angles, and Purkinje-ventricular-junction activation times. Thr ...[more]

PMID: 37479707

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Dataset Information

Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks.

Publications

Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks.

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