Effect of oral THC pretreatment on marijuana cue-induced responses in cannabis dependent volunteers.

ABSTRACT:

Background

The current study tested whether oral Δ(9)-tetrahydrocannabinol (THC: 0-, 10-, and 20-mg) pretreatment would attenuate polysensory cue-induced craving for marijuana.

Methods

Cannabis dependent participants (7 males and 7 females, who smoked on average 5.4 ± 1.1 blunts daily) completed 3 experimental sessions (oral THC pretreatment dose; counterbalanced order) using a placebo-controlled within-subject crossover design. During each session, participants completed a baseline evaluation and were first exposed to neutral cues then marijuana cues while physiological measures and subjective ratings of mood, craving, and drug effect were recorded.

Results

Following placebo oral THC pretreatment, marijuana (vs. neutral) cues significantly increased ratings of mariju

SUBMITTER: Lundahl LH 

PROVIDER: S-EPMC10369174 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature