The underlying molecular mechanisms and biomarkers between periodontitis and COVID-19.

ABSTRACT:

Objective

Emerging evidence shows the clinical consequences of patient with COVID-19 and periodontitis are not promising, and periodontitis is a risk factor. Periodontitis and COVID-19 probably have a relationship. Hence, this study aimed to identify the common molecular mechanism that may help to devise potential therapeutic strategies in the future.

Material and methods

We analyzed two RNA-seq datasets for differential expressed genes, enrichment of biological processes, transcription factors (TFs) and deconvolution-based immune cell types in periodontitis, COVID-19 and healthy controls. Relationships between TFs and mRNA were established by Pearson correlation analysis, and the common TFs-mRNA regulatory network and nine co-upregulated TFs of the two diseases was obtained

SUBMITTER: Qin D 

PROVIDER: S-EPMC10369766 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature