The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities.

ABSTRACT:

Background

Osteosarcoma is a highly aggressive malignant bone tumor that affects mainly adolescents and young adults. We analyzed serum biomarkers for their prognostic significance in children with osteosarcoma.

Methods

In this retrospective study, we investigated the prognostic factors in 210 children who were treated for appendicular osteosarcoma, including patient age and sex, tumor site and size (≥8 cm or <8 cm), presence of metastasis, chemotherapy-induced tumor necrosis, serum levels of alkaline phosphatase (AP), C-reactive protein, serum hemoglobin, lactate dehydrogenase, erythrocyte sedimentation rate (ESR), leukocyte counts, platelet count, and neutrophil-lymphocyte ratio.

Results

A multivariate Cox regression model showed that high level of AP [HR of 1.73; 9

SUBMITTER: Basoli S 

PROVIDER: S-EPMC10378558 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature