Total choline intake and working memory performance in adults with phenylketonuria.

ABSTRACT:

Background

Despite early diagnosis and compliance with phenylalanine (Phe)-restricted diets, many individuals with phenylketonuria (PKU) still exhibit neurological changes and experience deficits in working memory and other executive functions. Suboptimal choline intake may contribute to these impairments, but this relationship has not been previously investigated in PKU. The objective of this study was to determine if choline intake is correlated with working memory performance, and if this relationship is modified by diagnosis and metabolic control.

Methods

This was a cross-sectional study that included 40 adults with PKU and 40 demographically matched healthy adults. Web-based neurocognitive tests were used to assess working memory performance and 3-day dietary records we

SUBMITTER: Schoen MS 

PROVIDER: S-EPMC10386684 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature