Functional polymorphism in miR-208 is associated with increased risk for ischemic stroke.

ABSTRACT:

Background

The miR-208 gene is one of the microRNAs now under active studies, and has been found to play significant roles in an array of cardiovascular diseases. Nevertheless, until now, no studies have examined the relationship between the susceptibility to ischemic stroke (IS) and genetic variations in miR-208. This study explored the association between the miR-208 polymorphisms (rs178642, rs8022522, and rs12894524) and the risk of IS.

Methods

A total of 205 cases of IS and 211 control subjects were included. The SNPscans genotyping test was employed to determine the genotypes of the three polymorphisms.

Results

Significant correlation was observed between rs8022522 polymorphism and risk of IS on the basis of analyses of genotypes, models and alleles (GA vs. GG: a

SUBMITTER: Liu C 

PROVIDER: S-EPMC10391967 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature