Astragalus regulates the intestinal immune response during sepsis by mediating ILC3 proliferation through RORγt.

ABSTRACT:

Background

Sepsis is a common complication of many diseases and is associated with high morbidity and mortality rates. Astragalus can improve humoral and innate immunity, inhibit inflammatory responses, and protect immune cells and organs from damage. However, to the best of our knowledge there are no reports on whether astragalus can regulate intestinal innate immune function during sepsis.

Methods

In this study, a rat cecal ligation and puncture model of sepsis was used to investigate the effects of astragalus treatment, following which the apoptosis rate of lymphocytes from Peyer's patches (PP) was determined. Type 3 innate lymphoid cells (ILC3) were cultured in vitro to further evaluate the effects and mechanisms of astragalus.

Results

The apoptosis level of lymph

SUBMITTER: Li J 

PROVIDER: S-EPMC10395125 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature