Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure.

ABSTRACT:

Background

Given the increasing prevalence of wildfires worldwide, understanding the effects of wildfire air pollutants on human health-particularly in specific immunologic pathways-is crucial. Exposure to air pollutants is associated with cardiorespiratory disease; however, immune and epithelial barrier alterations require further investigation.

Objective

We sought to determine the impact of wildfire smoke exposure on the immune system and epithelial barriers by using proteomics and immune cell phenotyping.

Methods

A San Francisco Bay area cohort (n = 15; age 30 ± 10 years) provided blood samples before (October 2019 to March 2020; air quality index = 37) and during (August 2020; air quality index = 80) a major wildfire. Exposure samples were collected 11 days (range

SUBMITTER: Aguilera J 

PROVIDER: S-EPMC10399148 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature