First Total Synthesis of Tanzawaic Acid B.

ABSTRACT: The first total synthesis of (+)-tanzawaic acid B, a natural polyketide bearing a pentadienoic ester and octalin moiety, has been accomplished. The synthetic improvement from previous synthetic conditions facilitated our gram-scale synthesis of the chiral octalin that possesses seven stereogenic centers and that is the core skeleton of almost all of the tanzawaic acid family.

SUBMITTER: Murata T 

PROVIDER: S-EPMC10399178 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature