Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.

ABSTRACT:

Background

Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis.

Methods

We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test).

Results

Based on the joint tests, we

SUBMITTER: Dimou N 

PROVIDER: S-EPMC10403521 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature