Brain-targeted nanoreactors prevent the development of organophosphate-induced delayed neurological damage.

ABSTRACT:

Background

Organophosphate (OP)-induced delayed neurological damage is attributed to permanent neuropathological lesions caused by irreversible OP-neurocyte interactions, without potent brain-targeted etiological antidotes to date. The development of alternative therapies to achieve intracerebral OP detoxification is urgently needed.

Methods

We designed a brain-targeted nanoreactor by integrating enzyme immobilization and biomimetic membrane camouflaging protocols with careful characterization, and then examined its blood-brain barrier (BBB) permeability both in vitro and in vivo. Subsequently, the oxidative stress parameters, neuroinflammatory factors, apoptotic proteins and histopathological changes were measured and neurobehavioral tests were performed.

Results

The

SUBMITTER: Zou S 

PROVIDER: S-EPMC10405429 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature