Association between levothyroxine treatment for maternal subclinical hypothyroidism with negative TPOAb and early child neurodevelopment: A prospective real-world clinical trial.

ABSTRACT:

Introduction

Subclinical hypothyroidism (SCH) during pregnancy is reported to have detrimental impact on pregnancy and child development. However, its treatment indications require further investigation in different thyroid peroxidase antibody (TPOAb) status.

Material and methods

This was a secondary analysis of a Chinese prospective cohort in a real-world setting. Pregnant women with gestational SCH were enrolled at the first antenatal visit and grouped by TPOAb positivity. Child neurodevelopment was assessed by the Gesell development diagnosis scale (GDDS) at one, three, six, 12, and 24 months of age. Subgroup analyses and sensitivity analyses were also conducted.

Clinical trial registration

ClinicalTrials.gov NCT01744743.

Results

From January 2012 to Decembe

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC10407020 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature