Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury.

ABSTRACT:

Background

Bronchopulmonary dysplasia (BPD) is characterized by an arrest in lung development and is a leading cause of morbidity in premature neonates. It has been well documented that BPD disproportionally affects males compared to females, but the molecular mechanisms behind this sex-dependent bias remain unclear. Female mice show greater preservation of alveolarization and angiogenesis when exposed to hyperoxia, accompanied by increased miR-30a expression. In this investigation, we tested the hypothesis that loss of miR-30a would result in male and female mice experiencing similar impairments in alveolarization and angiogenesis under hyperoxic conditions.

Methods

Wild-type and miR-30a^-/- neonatal mice were exposed to hyperoxia [95% FiO₂, postnatal d

SUBMITTER: Grimm SL 

PROVIDER: S-EPMC10408139 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature