Nutritional and host environments determine community ecology and keystone species in a synthetic gut bacterial community.

ABSTRACT: A challenging task to understand health and disease-related microbiome signatures is to move beyond descriptive community-level profiling towards disentangling microbial interaction networks. Using a synthetic gut bacterial community, we aimed to study the role of individual members in community assembly, identify putative keystone species and test their influence across different environments. Single-species dropout experiments reveal that bacterial strain relationships strongly vary not only in different regions of the murine gut, but also across several standard culture media. Mechanisms involved in environment-dependent keystone functions in vitro include exclusive access to polysaccharides as well as bacteriocin production. Further, Bacteroides caecimuris and Blautia coccoides are fou

SUBMITTER: Weiss AS 

PROVIDER: S-EPMC10409746 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature