Adenosine A_2A receptor gene polymorphisms (ADORA2A) are associated with maximal concentric contraction pain.

ABSTRACT:

Objectives

To test associations of adenosine A_2A receptor gene (ADORA2A) polymorphisms with maximal concentric contraction pain, caffeine-induced perceptual changes, and responses to mild eccentric injury.

Design

Targeted candidate gene association study.

Methods

ADORA2A (rs5751876) was genotyped in 26 adults. Pain of a maximal elbow flexor contraction was assessed. Participants performed 18 eccentric actions of the elbow flexors. Arm volume was measured before and 24- and 48-h post-injury. At 24- and 48-h post-injury, caffeine or placebo capsules were given using a randomized cross-over design and effort and pain were assessed.

Results

Maximal concentric contraction pain was higher for the CC compared to the CT/TT group (effect size d

SUBMITTER: O'Connor PJ 

PROVIDER: S-EPMC10411232 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature