Dataset Information
Adenosine A2A receptor gene polymorphisms (ADORA2A) are associated with maximal concentric contraction pain.
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ABSTRACT: Objectives
To test associations of adenosine A2A receptor gene (ADORA2A) polymorphisms with maximal concentric contraction pain, caffeine-induced perceptual changes, and responses to mild eccentric injury.Design
Targeted candidate gene association study.Methods
ADORA2A (rs5751876) was genotyped in 26 adults. Pain of a maximal elbow flexor contraction was assessed. Participants performed 18 eccentric actions of the elbow flexors. Arm volume was measured before and 24- and 48-h post-injury. At 24- and 48-h post-injury, caffeine or placebo capsules were given using a randomized cross-over design and effort and pain were assessed.Results
Maximal concentric contraction pain was higher for the CC compared to the CT/TT group (effect size d = 0.89) and lower for the TT compared to the CT/CC group (d = 0.62). There were moderate sized differences between CC and TT/CT groups for post-injury exertion and arm volume 24-h post injury.Conclusions
ADORA2A polymorphisms are moderately associated with muscle pain during maximal contractions in uninjured muscle.
SUBMITTER: O'Connor PJ
PROVIDER: S-EPMC10411232 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Adenosine A<sub>2A</sub> receptor gene polymorphisms (ADORA2A) are associated with maximal concentric contraction pain.
Meta gene 20181201
<h4>Objectives</h4>To test associations of adenosine A<sub>2A</sub> receptor gene (<i>ADORA2A</i>) polymorphisms with maximal concentric contraction pain, caffeine-induced perceptual changes, and responses to mild eccentric injury.<h4>Design</h4>Targeted candidate gene association study.<h4>Methods</h4><i>ADORA2A</i> (rs5751876) was genotyped in 26 adults. Pain of a maximal elbow flexor contraction was assessed. Participants performed 18 eccentric actions of the elbow flexors. Arm volume was mea ...[more]