Characteristics of steroid hormones in systemic lupus erythematosus revealed by GC/MS-based metabolic profiling.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a remarkable predominance in female, suggesting that steroid hormones may be involved in the pathogenesis. However, steroid signature of SLE patients has not been fully explored.

Methods

A metabolic profiling analysis based on gas chromatography/mass spectrometry (GC/MS) with high sensitivity and reproducibility was employed to comprehensively reveal SLE-specific steroid alterations.

Results

More than 70 kinds of steroids in urine were detected by gas chromatography/mass spectrometry (GC/MS) to reveal SLE-specific steroid alterations. Principle component analysis demonstrated that the steroid profile was obviously distinguished between patients with SLE and controls. A lower level of t

SUBMITTER: Wu D 

PROVIDER: S-EPMC10415909 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature