Irisin Induces Apoptosis in Metastatic Prostate Cancer Cells and Inhibits Tumor Growth In Vivo.

ABSTRACT:

Background

Prostate cancer is the second most common cancer in males worldwide, with αVβ5 in-tegrin, a coactivator receptor, being highly expressed in advanced prostate cancer. Irisin, a hormone secreted from skeletal muscles, can reduce cell viability and migration and potentially inhibit αVβ5.

Objective

This study investigates the potential impact of irisin on prostate cancer cells and its underlying mechanism.

Methods

In vitro evaluation of the antiproliferative action of irisin on metastatic prostate cancer (PC-3) cells was tested through MTT assay, flow cytometry, and Western blot. An in vivo evaluation of the antiproliferative effect on prostate cancer xenograft was evaluated in nude mice.

Results

In vitro evaluations showed that irisin reduced PC-3 cell

SUBMITTER: Alshanqiti KH 

PROVIDER: S-EPMC10416853 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature