Clinical features and brain MRI volumetric changes in anti-mGluR5 encephalitis.

ABSTRACT:

Background

Anti-metabotropic glutamate receptor 5 (mGluR5) encephalitis is a rare and under-recognized autoimmune encephalitis. This study is conducted to characterize its clinical and neuroimaging features.

Methods

Twenty-nine patients with anti-mGluR5 encephalitis (15 new cases identified in this study and 14 previously reported cases) were included in this study and their clinical features were characterized. Brain MRI volumetric analysis using FreeSurfer software was performed in 9 new patients and compared with 25 healthy controls at both early (≤6 months of onset) and chronic (>1 year of onset) disease stages.

Results

The common clinical manifestations of anti-mGluR5 encephalitis included cognitive deficits (n = 21, 72.4%), behavioral and mood disturbances (n = 

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10424662 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature