Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity.

ABSTRACT:

Background

C-to-U RNA editing in plants is believed to confer its evolutionary adaptiveness by reversing unfavorable DNA mutations. This "restorative hypothesis" has not yet been tested genome-wide. In contrast, A-to-I RNA editing in insects like Drosophila and honeybee is already known to benefit the host by increasing proteomic diversity in a spatial-temporal manner (namely "diversifying hypothesis").

Methods

We profiled the RNA editomes of multiple tissues of Arabidopsis thaliana, Drosophila melanogaster, and Apis melifera. We unprecedentedly defined the haplotype diversity (HD) of RNA molecules based on nonsynonymous editing events (recoding sites).

Results

Signals of adaptation is confirmed in Arabidopsis by observing higher frequencies and levels at nonsynonymou

SUBMITTER: Duan Y 

PROVIDER: S-EPMC10433597 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature