Association of Physical Activity and Parkinson Disease in Women: Long-term Follow-up of the E3N Cohort Study.

ABSTRACT:

Background and objectives

Previous cohort studies reported that a single measure of physical activity (PA) assessed at baseline was associated with lower Parkinson disease (PD) incidence, but a meta-analysis suggested that this association was restricted to men. Because of the long prodromal phase of the disease, reverse causation could not be excluded as a potential explanation. Our objective was to study the association between time-varying PA and PD in women using lagged analyses to address the potential for reverse causation and to compare PA trajectories in patients before diagnosis and matched controls.

Methods

We used data from the Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale (1990-2018), a cohort study of women affiliated wi

SUBMITTER: Portugal B 

PROVIDER: S-EPMC10435054 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature