Cathepsin S activity controls chronic stress-induced muscle atrophy and dysfunction in mice.

ABSTRACT: Exposure to chronic psychological stress (CPS) is an intractable risk factor for inflammatory and metabolic diseases. Lysosomal cysteinyl cathepsins play an important role in human pathobiology. Given that cathepsin S (CTSS) is upregulated in the stressed vascular and adipose tissues, we investigated whether CTSS participates in chronic stress-induced skeletal muscle mass loss and dysfunction, with a special focus on muscle protein metabolic imbalance and apoptosis. Eight-week-old male wildtype (CTSS^+/+) and CTSS-knockout (CTSS^-/-) mice were randomly assigned to non-stress and variable-stress groups. CTSS^+/+ stressed mice showed significant losses of muscle mass, dysfunction, and fiber area, plus significant mitochondrial damage. In this setting, stressed m

SUBMITTER: Wan Y 

PROVIDER: S-EPMC10435624 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature