HTLV-1 p12 modulates the levels of prion protein (PrP^C) in CD4⁺ T cells.

ABSTRACT:

Introduction

Infection with human T cell lymphotropic virus type 1 (HTLV-1) is endemic in Brazil and is linked with pro-inflammatory conditions including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic neuroinflammatory incapacitating disease that culminates in loss of motor functions. The mechanisms underlying the onset and progression of HAM/TSP are incompletely understood. Previous studies have demonstrated that inflammation and infectious agents can affect the expression of cellular prion protein (PrP^C) in immune cells.

Methods

Here, we investigated whether HTLV-1 infection affected PrP^C content in cell lines and primary CD4⁺cells in vitro using flow cytometry and western blot assays.

Results

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SUBMITTER: Silva De Castro I 

PROVIDER: S-EPMC10449582 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature