Nitroxide-HMP-Protects Human Trophoblast HTR-8/SVneo Cells from H₂O₂-Induced Oxidative Stress by Reducing the HIF1A Signaling Pathway.

ABSTRACT: Preeclampsia (PE) is a pregnancy-specific syndrome affecting 5-7% of patients. There is no effective treatment available. Early abnormal placental development is associated with oxidative stress (OS) and a release of reactive oxygen species (ROS) in the placenta. This phenomenon leads to downstream signaling, Hypoxia Inducible Factor 1A (HIF1A) stabilization and transcription of the anti-angiogenic factors soluble fms-like tyrosine kinase 1 (sFLT1) and soluble endoglin (sEng), which are known to cause endothelial and trophoblast dysfunction and cardinal features of PE: hypertension, proteinuria and, in severe cases, eclampsia. We tested whether 3-(Hydroxymethyl)-1-oxy-2,2,5,5-tetramethylpyrrolidine (HMP)-a nitroxide-type antioxidant molecule-can reduce placental OS and mitigate PE symptoms

SUBMITTER: Pintye D 

PROVIDER: S-EPMC10451835 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature