TRMT61B rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers.

ABSTRACT: N¹-methyladenosine (m¹A) is an essential chemical modification of RNA. Dysregulation of RNA m¹A modification and m¹A-related regulators is detected in several adult tumors. Whether aberrant RNA m¹A modification is involved in hepatoblast carcinogenesis has not been reported. tRNA methyltransferase 61B (TRMT61B) is responsible for mitochondrial RNA m¹A modification. Some evidence has shown that genetic variants of TRMT61B might contribute to cancer susceptibility; however, its roles in hepatoblastoma are unknown. This study attempted to discover novel hepatoblastoma susceptibility loci. With the TaqMan method, we examined genotypes of the TRMT61B rs4563180 G>C polymorphism among germline DNA samples from 313 cas

SUBMITTER: Zeng D 

PROVIDER: S-EPMC10457066 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature