Evaluation of Strategies for Reducing Vancomycin-Piperacillin/Tazobactam Incompatibility.

ABSTRACT:

Background

Drug incompatibility is defined as a physical-chemical reaction between two or more injectable drugs and that results mainly in precipitation or insolubility. Several strategies for reducing incompatibilities have been implemented empirically in intensive care units. However, these strategies have never been compared directly (and particularly in terms of the particulate load and drug mass flow rate) under standardized conditions. The objective of the present in vitro study was to evaluate the impact of various strategies for preventing incompatibility between simultaneously infused vancomycin and piperacillin/tazobactam.

Methods

An in-line filter, a dilute vancomycin solution (5 mg/mL), and an alternative saline administration line were evaluated separately. The

SUBMITTER: Martin Mena A 

PROVIDER: S-EPMC10459903 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature