Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts.

ABSTRACT:

Background

Diabetes mellitus (DM), either preexisting or developing after transplantation, remains a crucial clinical problem in kidney transplantation. To obtain insights into the molecular mechanisms underlying PTDM development and early glomerular damage before the development of histologically visible diabetic kidney disease, we comparatively analysed the proteome of histologically normal glomeruli from patients with PTDM and normoglycaemic (NG) transplant recipients. Moreover, to assess specificities inherent in PTDM, we also comparatively evaluated glomerular proteomes from transplant recipients with preexisting type 2 DM (T2DM).

Methods

Protocol biopsies were obtained from adult NG, PTDM and T2DM patients one year after kidney transplantation. Biopsies were formalin-f

SUBMITTER: Kipp A 

PROVIDER: S-EPMC10464146 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature