Different associations between amyloid-βeta 42, amyloid-βeta 40, and amyloid-βeta 42/40 with soluble phosphorylated-tau and disease burden in Alzheimer's disease: a cerebrospinal fluid and fluorodeoxyglucose-positron emission tomography study.

ABSTRACT:

Background

Despite the high sensitivity of cerebrospinal fluid (CSF) amyloid beta (Aβ)₄₂ to detect amyloid pathology, the Aβ₄₂/Aβ₄₀ ratio (amyR) better estimates amyloid load, with higher specificity for Alzheimer's disease (AD). However, whether Aβ₄₂ and amyR have different meanings and whether Aβ₄₀ represents more than an Aβ₄₂-corrective factor remain to be clarified. Our study aimed to compare the ability of Aβ₄₂ and amyR to detect AD pathology in terms of p-tau/Aβ₄₂ ratio and brain glucose metabolic patterns using fluorodeoxyglucose-positron emission tomography (FDG-PET).

Methods

CSF biomarkers were analyzed with EUROIMMUN ELISA. We included 163 patients showing pathological CSF Aβ

SUBMITTER: Motta C 

PROVIDER: S-EPMC10466826 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature