Smoking during pregnancy and its effect on placental weight: A Mendelian randomization study.

ABSTRACT:

Background

The causal relationship between maternal smoking in pregnancy and reduced offspring birth weight is well established and is likely due to impaired placental function. However, observational studies have given conflicting results on the association between smoking and placental weight. We aimed to estimate the causal effect of newly pregnant mothers quitting smoking on their placental weight at the time of delivery.

Methods

We used one-sample Mendelian randomization, drawing data from the Avon Longitudinal Study of Parents and Children (ALSPAC) (up to N = 805) and the Norwegian Mother, Father and Child Cohort Study (MoBa) (up to N = 4475). The analysis was performed in pre-pregnancy smokers only, due to the specific role of the genetic instrument SNP rs1051730 (

SUBMITTER: Jaitner A 

PROVIDER: S-EPMC10473803 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature