Clinical consequences of a polygenic predisposition to benign lower white blood cell counts: Consequences of benign WBC count genetics.
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SUBMITTER: Mosley JD
PROVIDER: S-EPMC10473820 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
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Clinical consequences of a polygenic predisposition to benign lower white blood cell counts: Consequences of benign WBC count genetics.
Mosley Jonathan D JD Shelley John P JP Dickson Alyson L AL Zanussi Jacy J Daniel Laura L LL Zheng Neil S NS Bastarache Lisa L Wei Wei-Qi WQ Shi Mingjian M Jarvik Gail P GP Rosenthal Elisabeth A EA Khan Atlas A Sherafati Alborz A Kullo Iftikhar J IJ Walunas Theresa L TL Glessner Joe J Hakonarson Hakon H Cox Nancy J NJ Roden Dan M DM Frangakis Stephan G SG Vanderwerff Brett B Stein C Michael CM Van Driest Sara L SL Borinstein Scott C SC Shu Xiao-Ou XO Zawistowski Matthew M Chung Cecilia P CP Kawai Vivian K VK
medRxiv : the preprint server for health sciences 20230821
Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is undefined. We investigated the clinical consequences of a genetic predisposition toward lower WBC counts among 89,559 biobank participants from tertiary care centers using a polygenic score for WBC count (PGS<sub>WBC</sub>) comprising single nucleotide polymorphisms not associated with disease. A predisposition to lower WBC counts was assoc ...[more]
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