TM4SF5-mediated abnormal food-intake behavior and apelin expression facilitate non-alcoholic fatty liver disease features.
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ABSTRACT:
SUBMITTER: Pinanga YD
PROVIDER: S-EPMC10475478 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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TM4SF5-mediated abnormal food-intake behavior and apelin expression facilitate non-alcoholic fatty liver disease features.
Pinanga Yangie Dwi YD Lee Han Ah HA Shin Eun-Ae EA Lee Haesong H Pyo Kyung-Hee KH Kim Ji Eon JE Lee Eun Hae EH Kim Wonsik W Kim Soyeon S Kim Hwi Young HY Lee Jung Weon JW
iScience 20230814 9
Transmembrane 4 L six family member 5 (TM4SF5) engages in non-alcoholic steatohepatitis (NASH), although its mechanistic roles are unclear. Genetically engineered <i>Tm4sf5</i> mice fed <i>ad libitum</i> normal chow or high-fat diet for either an entire day or a daytime-feeding (DF) pattern were analyzed for metabolic parameters. Compared to wild-type and <i>Tm4sf5</i><sup>-/-</sup> knockout mice, hepatocyte-specific TM4SF5-overexpressing <i>Alb</i>-TG<sup>Tm4sf5-Flag</sup> (TG) mice showed abno ...[more]
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