N⁶ -methyladenosine-modified FAM111A-DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A.

ABSTRACT: As an epitranscriptomic modulation manner, N⁶ -methyladenosine (m⁶ A) modification plays important roles in various diseases, including hepatocellular carcinoma (HCC). m⁶ A modification affects the fate of RNAs. The potential contributions of m⁶ A to the functions of RNA still need further investigation. In this study, we identified long noncoding RNA FAM111A-DT as an m⁶ A-modified RNA and confirmed three m⁶ A sites on FAM111A-DT. The m⁶ A modification level of FAM111A-DT was increased in HCC tissues and cell lines, and increased m⁶ A level was correlated with poor survival of HCC patients. m⁶ A modification increased the stability of FAM111A-DT transcript, whose expression level showed simil

SUBMITTER: Pu J 

PROVIDER: S-EPMC10475779 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature