Rhinoviruses A and C elicit long-lasting antibody responses with limited cross-neutralization.

ABSTRACT: Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has been hampered by the multitude of RV types with little information about cross-neutralization. We previously showed that neutralizing antibody (nAb) responses to RV-C are detected twofold to threefold more often than those to RV-A throughout childhood. Based on those findings, we hypothesized that RV-C infections are more likely to induce either cross-neutralizing or longer-lasting antibody responses compared with RV-A infections. We pooled RV diagnostic data from multiple studies of children with respiratory illnesses and compared the expected versus observed frequencies of sequential infections with RV-A or RV-C types using log-linear regression models. We tested lon

SUBMITTER: Bochkov YA 

PROVIDER: S-EPMC10484091 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature