Olfactory dysfunction after autoimmune encephalitis depending on the antibody type and limbic MRI pathologies.

ABSTRACT:

Objective

Patients' olfactory function after autoimmune encephalitis (AE) involving limbic structures may be impaired. This study aimed to characterize olfactory function in patients after autoimmune encephalitides.

Methods

A case-control study was performed including 11 AE patients with antibodies against NMDAR (n = 4), GAD (n = 3), VGKC (n = 3) and antibody-negative AE (n = 1) and a control group of 12 patients with pneumococcal meningo-encephalitis (PC). In subgroup analyses, AE patients with and without NMDAR-antibodies were compared. Olfactory function was assessed using the Sniffin Sticks test and the resulting TDI-score (threshold, discrimination, identification). Involvement of limbic structures was evaluated on imaging data (MRI). Statist

SUBMITTER: Hansel M 

PROVIDER: S-EPMC10486887 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature