Ascites-Derived Organoids to Depict Platinum Resistance in Gynaecological Serous Carcinomas.

ABSTRACT: Gynaecological serous carcinomas (GSCs) constitute a distinctive entity among female tumours characterised by a very poor prognosis. In addition to late-stage diagnosis and a high rate of recurrent disease associated with massive peritoneal carcinomatosis, the systematic acquisition of resistance to first-line chemotherapy based on platinum determines the unfavourable outcome of GSC patients. To explore the molecular mechanisms associated with platinum resistance, we generated patient-derived organoids (PDOs) from liquid biopsies of GSC patients. PDOs are emerging as a relevant preclinical model system to assist in clinical decision making, mainly from tumoural tissue and particularly for personalised therapeutic options. To approach platinum resistance in a GSC context, proficient PDOs we

SUBMITTER: Arias-Diaz AE 

PROVIDER: S-EPMC10487816 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature