Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis.

ABSTRACT:

Purpose

This study aimed to explore whether umbilical cord-derived mesenchymal stem cells (UC-MSCs) could be used as a therapeutic resource for endometriosis.

Methods

Of seven cynomolgus monkeys with endometriosis, five were administered UC-MSCs (intervention group) and two were administered saline (control group). First, intravenous US-MSC treatment was administered for three months. Second, weekly intravenous US-MSC administration combined with monthly intraperitoneal US-MSC administration was conducted for 3 months. Finally, weekly intraperitoneal US-MSC administration was conducted for 3 months. The dose of UC-MSCs was set to 2 × 10⁶ cells/kg for all administration routes. Laparoscopic findings and serum cancer antigen 125 (CA125) levels were also evaluated. T

SUBMITTER: Tsuji S 

PROVIDER: S-EPMC10491929 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature