Dominant constraints on the evolution of rhythmic gene expression.

ABSTRACT: Although the individual transcriptional regulators of the core circadian clock are distinct among different organisms, the autoregulatory feedback loops they form are conserved. This unified design principle explains how daily physiological activities oscillate across species. However, it is unknown whether analogous design principles govern the gene expression output of circadian clocks. In this study, we performed a comparative analysis of rhythmic gene expression in eight diverse species and identified four common distribution patterns of cycling gene expression across these species. We hypothesized that the maintenance of reduced energetic costs constrains the evolution of rhythmic gene expression. Our large-scale computational simulations support this hypothesis by showing that select

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC10492206 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature