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Clinical Characteristics of Rapid Progression in Asia-Pacific Patients With ADPKD.


ABSTRACT:

Introduction

This study aimed to determine the utility of different methods to predict rapid progressors (RPs) and their clinical characteristics in Asia-Pacific patients with autosomal dominant polycystic kidney disease (ADPKD).

Methods

This was a multinational retrospective observational cohort study of patients with ADPKD in the Asia-Pacific region. Five hospitals from Australia, China, South Korea, Taiwan, and Turkey participated in this study. RP was defined by European Renal Association-European Dialysis and Transplantation Association (ERA-EDTA) guidelines and compared to slow progressors (SPs).

Results

Among 768 patients, 426 patients were RPs. Three hundred six patients met only 1 criterion and 120 patients satisfied multiple criteria for RP. Historical estimated glomerular filtration rate (eGFR) decline fulfilled the criteria for RP in 210 patients. Five patients met the criteria for a historical increase in height-adjusted total kidney volume (TKV). The 210 patients satisfied the criteria for based on kidney volume. During the follow-up period, cyst infections, cyst hemorrhage, and proteinuria occurred more frequently in RP; and 13.9% and 2.1% of RPs and SPs, respectively, progressed to end-stage kidney disease (ESKD). RP criteria based on historical eGFR decline had the strongest correlation with eGFR change over a 2-year follow-up.

Conclusion

Various assessment strategies should be used for identifying RPs among Asian-Pacific patients with ADPKD in real-world clinical practice during the follow-up period, cyst infections, cyst hemorrhage, and proteinuria occurred more frequently; and more patients progressed to ESKD in RPs compared with SPs.

SUBMITTER: Oh YK 

PROVIDER: S-EPMC10496076 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

Clinical Characteristics of Rapid Progression in Asia-Pacific Patients With ADPKD.

Oh Yun Kyu YK   Ryu Hyunjin H   Ahn Curie C   Park Hayne C HC   Ma Yiyi Y   Xu Dechao D   Ecder Tevfik T   Kao Tze-Wah TW   Huang Jeng-Wen JW   Rangan Gopala K GK  

Kidney international reports 20230626 9


<h4>Introduction</h4>This study aimed to determine the utility of different methods to predict rapid progressors (RPs) and their clinical characteristics in Asia-Pacific patients with autosomal dominant polycystic kidney disease (ADPKD).<h4>Methods</h4>This was a multinational retrospective observational cohort study of patients with ADPKD in the Asia-Pacific region. Five hospitals from Australia, China, South Korea, Taiwan, and Turkey participated in this study. RP was defined by European Renal  ...[more]

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