The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD) are associated, but it is unclear if this is a causal relationship or confounding. We used genetic analyses and sibling comparisons to clarify the direction of this relationship.

Methods

Linkage disequilibrium score regression and 2-sample Mendelian randomization were used to test for genetic correlation (r_g) and bidirectional causal effects using European ancestry genome-wide association studies of ADHD (20,183 cases and 35,191 controls) and 6 PTSD definitions (up to 320,369 individuals). Several additional variables were included in the analysis to verify the independence of the ADHD-PTSD relationship. In a population-based sibling comparison (N = 2,082,118 indivi

SUBMITTER: Wendt FR 

PROVIDER: S-EPMC10496427 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature