Ontology highlight
ABSTRACT:
SUBMITTER: Huo Q
PROVIDER: S-EPMC10497626 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Huo Qingji Q Li Kexin K Sun Xun X Zhuang Adam A Minami Kazumasa K Tamari Keisuke K Ogawa Kazuhiko K Fishel Melissa L ML Li Bai-Yan BY Yokota Hiroki H
Scientific reports 20230912 1
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival. To explore an uncharted function of K-Ras proto-oncogene, K-Ras was activated in mesenchymal stem cells (MSCs) and the effects of MSC conditioned medium (CM) on PDAC were examined. Overexpression of K-Ras elevated PI3K signaling in MSCs, and K-Ras/PI3K-activated MSC-derived CM reduced the proliferation and migration of tumor cells, as well as the growth of ex vivo freshly isolated human PDAC cultures. CM's anti-t ...[more]