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Metal-free, photoinduced remote C(sp³)-H borylation.

ABSTRACT: Here, we describe a protocol for the metal-free, photo-induced borylation of unactivated C(sp³)-H bonds distal to an O-oxalate hydroxamic ester functionality. The methodology requires only substrate and bis(catecholato)diboron under light irradiation to effect the desired transformation. A range of linear and cyclic tertiary and secondary borylation products are obtained in good yields and high site-selectivity enabling the late-stage C(sp³)-H borylation of natural product derivatives and drug-like compounds.

SUBMITTER: He J

PROVIDER: S-EPMC10498503 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Metal-free, photoinduced remote C(sp3)-H borylation.

He Jiachen J Cook Silas P SP

Chemical science 20230822 35

Here, we describe a protocol for the metal-free, photo-induced borylation of unactivated C(sp3)-H bonds distal to an O-oxalate hydroxamic ester functionality. The methodology requires only substrate and bis(catecholato)diboron under light irradiation to effect the desired transformation. A range of linear and cyclic tertiary and secondary borylation products are obtained in good yields and high site-selectivity enabling the late-stage C(sp3)-H borylation of natural p ...[more]

PMID: 37712044

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