Reductive photoredox transformations of carbonyl derivatives enabled by strongly reducing photosensitizers.

ABSTRACT: Visible-light photoredox catalysis is well-established as a powerful and versatile organic synthesis strategy. However, some substrate classes, despite being attractive precursors, are recalcitrant to single-electron redox chemistry and thus not very amenable to photoredox approaches. Among these are carbonyl derivatives, e.g. ketones, aldehydes, and imines, which in most cases require Lewis or Brønsted acidic additives to activate via photoinduced electron transfer. In this work, we unveil a range of photoredox transformations on ketones and imines, enabled by strongly reducing photosensitizers and operating under simple, general conditions with a single sacrificial reductant and no additives. Specific reactions described here are umpolung C-C bond forming reactions between

SUBMITTER: Dang VQ 

PROVIDER: S-EPMC10498680 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature