Overexpression of CD73 is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues.

ABSTRACT:

Background

For various cancers, differences in response to treatment and subsequent survival period have been reported to be associated with variation in immune contextures.

Aim

We sought to identify whether such association exists in respect of gingivobuccal oral cancer.

Materials and methods

We performed deep immune profiling of tumor and margin tissues collected from 46 treatment naïve, Human Papillomavirus (HPV) negative, patients. Each patient was followed for 24 months and prognosis (recurrence/death) noted. Key findings were validated by comparing with TCGA-HNSC cohort data.

Results

About 28% of patients showed poor post-treatment prognosis. These patients exhibited a high probability of recurrence even within 1 year and death within 2 years. There was r

SUBMITTER: Chatterjee A 

PROVIDER: S-EPMC10501293 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature