Establishing a health-based recommended occupational exposure limit for isoflurane using experimental animal data: a systematic review protocol.

ABSTRACT:

Background

Isoflurane is used as an inhalation anesthetic in medical, paramedical, and veterinary practice. Epidemiological studies suggest an increased risk of miscarriages and malformations at birth related to maternal exposure to isoflurane and other inhalation anesthetics. However, these studies cannot be used to derive an occupational exposure level (OEL), because exposure was not determined quantitatively and other risk factors such as co-exposures to other inhalation anesthetics and other work-related factors may also have contributed to the observed adverse outcomes. The aim of this systematic review project is to assess all available evidence on the effects of isoflurane in studies of controlled exposures in laboratory animals to derive a health-based recommended OEL.

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SUBMITTER: Struijs F 

PROVIDER: S-EPMC10503167 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature