Dysmetabolism-related Early Sensory Deficits and Their Relationship With Peripheral Neuropathy Development.

ABSTRACT:

Aim

To investigate the association of early peripheral sensory dysfunction (EPSD) identified through quantitative sensory testing (QST) with factors related to a dysmetabolic status in individuals with and without type 2 diabetes (T2DM) without peripheral neuropathy (PN), and the impact of those factors on PN development.

Methods

A total of 225 individuals (117 and 108 without and with T2DM, respectively) without PN based on clinical and electrophysiological criteria were analyzed. Comparative analysis was conducted between those identified as "healthy" and those with EPSD based on a standardized QST protocol. A total of 196 were followed-up over a mean of 2.64 years for PN occurrence.

Results

Among those without T2DM, apart from male sex, height, and higher fat and l

SUBMITTER: Tsilingiris D 

PROVIDER: S-EPMC10505541 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature