Dataset Information

Potential risk factors and genetic variants associated with dental caries incidence in Appalachia using genome-wide survival analysis.

ABSTRACT:

Objective

The aim of this study was to identify the potential risk factors and genetic variants associated with dental caries incidence using survival analysis.

Methods

The Center for Oral Health Research in Appalachia recruited and prospectively followed pregnant women and their children. A total of 909 children followed from birth for up to 7 years were included in this study. Annual intra-oral examinations were performed to assess dental caries experience including the approximate time to first caries incidence in the primary dentition. Cox proportional hazards models were used to assess the associations of time to first caries incidence with self-reported risk factors and 4.9 million genetic variants ascertained using a genome-wide genotyping array.

Results

A total of 196 of 909 children (21.56%) had their first primary tooth caries event during follow-up. Household income, home water source, and mother's educational attainment were significantly associated with time to first caries incidence in the stepwise Cox model. The heritability (i.e., proportion of variance explained by genetics) of time to first caries was 0.54. Though no specific genetic variants were associated at the genome-wide significance level (P < 5E-8), we identified 14 loci at the suggestive significance level (5E-8 < P < 1E-5), some of which were located within or near genes with plausible biological functions in dental caries.

Conclusion

Our findings indicate that household income, home water source, and mother's educational attainment are independent risk factors for dental caries incidence. We nominate several suggestive loci for further investigation.

SUBMITTER: Zou T

PROVIDER: S-EPMC10509536 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Potential risk factors and genetic variants associated with dental caries incidence in Appalachia using genome-wide survival analysis.

Zou Tianyu T Neiswanger Katherine K Feingold Eleanor E Foxman Betsy B McNeil Daniel W DW Marazita Mary L ML Shaffer John R JR

International journal of molecular epidemiology and genetics 20230815 2

<h4>Objective</h4>The aim of this study was to identify the potential risk factors and genetic variants associated with dental caries incidence using survival analysis.<h4>Methods</h4>The Center for Oral Health Research in Appalachia recruited and prospectively followed pregnant women and their children. A total of 909 children followed from birth for up to 7 years were included in this study. Annual intra-oral examinations were performed to assess dental caries experience including the approxim ...[more]

PMID: 37736056

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Project description:BACKGROUND:The pathogenesis of dental caries remains unclear, with increasing evidence suggesting that genetic susceptibility plays an essential role. Previous studies have reported the association between genetic polymorphisms in lactotransferrin (LTF) and the risk of dental caries with inconsistent results. METHODS:A systematic literature search of the PubMed, Cochrane Library, HuGE and Google Scholar databases was performed by two authors independently for papers published before December 5, 2019 on the association between genetic variants in LTF and the risk of dental caries. We adopted the subsequent inclusion criteria to assess study eligibility: 1) The studies were based on human subjects; 2) the presence of dental caries should be screened for in both the case group and the control group; and 3) genotype data on variants in LTF were available in both the case group and the control group. We calculated odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by using random-effects models to assess the association of genetic variants in LTF with the risk of dental caries. We also performed a gene-based analysis to explore the joint association of multiple genetic variants in LTF with the risk of dental caries. RESULTS:Our systematic literature search identified six relevant papers for analysis. We found no significant association between rs1126478 and the risk of dental caries when meta-analysing the genotype distribution between subjects with dental caries and those without dental caries (additive model: OR = 1.41; 95% CI = 0.98-2.02; P = 0.065). However, further analysis indicated that rs1126478 was associated with dental risk in subjects who had moderate or severe dental caries compared to those without dental caries (P < 0.0001). The gene-based analysis indicated that multiple genetic variants in LTF were jointly associated with the risk of dental caries (P = 0.002). CONCLUSIONS:The present meta-analysis revealed some evidence of the association between rs1126478 and dental caries and that multiple genetic variants in LTF are jointly associated with the risk of dental caries. Our findings need to be validated by larger studies that adjust for important confounding factors for the risk of dental caries.

Dataset Information

Potential risk factors and genetic variants associated with dental caries incidence in Appalachia using genome-wide survival analysis.

Objective

Methods

Results

Conclusion

Publications

Potential risk factors and genetic variants associated with dental caries incidence in Appalachia using genome-wide survival analysis.

Similar Datasets

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