Potential risk factors and genetic variants associated with dental caries incidence in Appalachia using genome-wide survival analysis.

ABSTRACT:

Objective

The aim of this study was to identify the potential risk factors and genetic variants associated with dental caries incidence using survival analysis.

Methods

The Center for Oral Health Research in Appalachia recruited and prospectively followed pregnant women and their children. A total of 909 children followed from birth for up to 7 years were included in this study. Annual intra-oral examinations were performed to assess dental caries experience including the approximate time to first caries incidence in the primary dentition. Cox proportional hazards models were used to assess the associations of time to first caries incidence with self-reported risk factors and 4.9 million genetic variants ascertained using a genome-wide genotyping array.

Results

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SUBMITTER: Zou T 

PROVIDER: S-EPMC10509536 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature